Madeleine Finlay sits down with her co-host and Guardian science editor, Ian Sample, to discuss three science stories from the week, including a study that offers a clue in the age-old debate about whether sex differences are present from birth or a product of socialisation. Also on the agenda is the super El Niño, which is predicted to lead to 450,000 deaths in the next six months, and an answer to why the UK’s meningitis outbreak earlier this year was so big.

In early September, OpenAI announced it had solved a major mathematics problem that has stumped humans for nearly a century. The news left mathematicians reeling, and many expressed concern over what will be left for humans as AI becomes ever more adept at unravelling complex problems. Now 25 recipients of the Fields medal – often called the Nobel prize for maths – have signed an open letter expressing their fears of a ‘severe misalignment’ between AI companies and their field. To find out how AI is likely to upend maths – and how mathematicians might respond – Ian Sample speaks to Colva Roney-Dougal, professor of pure mathematics at the University of St Andrews